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Li Ka Shing Institute of Virology

Dr. Michael Houghton’s HCV Research makes big progress

Posted by karin.fodor on September 28, 2017
Posted in News 

The latest publications from the Houghton lab:

Marawan Ahmed, Horia H. Jalily, Aravindhan Ganesan, Michael Houghton and Khaled Barakat (2017) A Comprehensive Model of the Human Nav1.5 Sodium Channel: Structural and Mechanistic Insights of Ion Permeation & Drug Blockage. Drug Design, Development and Therapy (Accpeted)

Michael Logan, John Law, Jason Alexander Ji-Xhin Wong, Darren Hockman, Amir Landi, Chao Chen, CrCrcrawfordCrawford, Kevin Crawford, Juthika Kundu, Lesley Baldwin, Janelle Johnson, Anita Dahiya, Gerald LaChance, Joseph Marcotrigiano, Mansun Law, Steven Foung, Lorne Tyrrell, and Michael Houghton (2017) Native Folding of a Recombinant gpE1/gpE2 Heterodimer Vaccine Antigen from a Precursor Protein Fused with Fc IgG. J. Virol. January 91:1 14 doi:10.1128/JVI.01552-16

N.S. Pagadala, K. Sahu, R. Bhat, K. Syed, M. Houghton and J.A. Tuszynski (2017) In silico Strategies for Designing Anti-prion Compounds, Expert Opinion on Drug Discovery, 2017 Mar;12(3):241-248. doi: 10.1080/17460441.2017.1287171. Epub 2017 Feb 2. Review. PMID: 28118747

Santer DM, Minty GE, Mohamed A, Baldwin L, Bhat R, Joyce M, Egli A, Tyrrell DLHoughton M. (2017) A novel method for detection of IFN-lambda 3 binding to cells for quantifying IFN-lambda receptor expression. J Immunol Methods. doi:10.1016/j.jim.2017.03.001.

Santer D, Baldwin L, Tyrrell DLJ, Mohamed A, Houghton M, Joyce M, Minty G, Bhat R, Egli A.  (2017) A novel method for detection of IFN-lambda 3 binding to cells for quantifying IFN-lambda receptor expression.  J Immunol Methods. 2017 Mar 5. pii: S0022-1759(17)30004-2. doi: 10.1016/j.jim.2017.03.001. [Epub ahead of print]

Sarhan M, Abdel-Hakeem M, Mason A, Tyrrell DLJ, Houghton M.  Glycogen synthase kinase 3ß inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism.  Nature Scientific Reports Published Online May 31, 2017

Mohammed A. Sarhan, Mohamed S. Abdel-Hakeem, Ishwar Hossmani, Lorne Tyrrell, Andrew Mason and Michael Houghton. (2017) GSK3b inhibitors prevent HCV release/assembly through perturbation of lipid metabolism. Nature Scientific Reports in press

 

Dr. Sonja M. Best

Posted by karin.fodor on September 21, 2017
Posted in Uncategorized 

Dr. Sonja M. Best -Chief Innate Immunity and Pathogens Section, Rocky Mountain Laboratories, Hamilton MT

“Beyond Retroviruses: Restriction of flavivirus replication by TRIM5”

10:00AM – Oborowsky Degner Seminar Hall (1-040 Li Ka Shing Building)
Reception to follow
12th Annual D. Lorne Tyrrell Lectureship in Infection & Immunity sponsored by the Tyrrell Endowment Fund

Dr. Michael Hawkes

Posted by karin.fodor on September 14, 2017
Posted in Uncategorized 

Dr. Michael Hawkes -Assistant Professor, University of Alberta, Pediatrics

“Neuroprotective adjunctive agents for crebral malaria”

4:00PM – Classroom F (2J4.02 Walter Mackenzie Health Science Centre)
ImmuNet Seminar Series, Department of Medical Microbiology & Immunology
Host: Dr. Maya Shmulevitz – Seminar Chair
Sponsors: Muttart Immunology Network

Dominic Golec

Posted by karin.fodor on September 8, 2017
Posted in Seminars 

Dominic Golec -Baldwin Lab

“Regulation of T cell development by RasGRPs 1 and 3”

9:00AM – Oborowsky Degner Seminar Hall (1-040 Li Ka Shing Building)
PhD Thesis Seminar; Department of Medical Microbiology & Immunology

Dr. Michele Anderson

Posted by karin.fodor on September 7, 2017
Posted in Seminars 

Dr. Michele Anderson -Associate Professor, University of Toronto, Sunnybrook Reserach Institute

“Transcriptional control of gamma delta T cell development by HEB transcription factors”

10:00AM – Oborowsky Degner Seminar Hall (1-040 Li Ka Shing Building)
Host: Dr. Troy Baldwin – MMI
Sponsors: The Walter Mackenzie Visiting Speaker Fund and the Faculty of Graduate Studies